Cell-Penetrating Peptides(CPPs) and Drug Delivery
Cell-Penetrating Peptides (CPPs) possess the remarkable ability to deliver pharmacologically active compounds—such as proteins, plasmid DNA, liposomes, and nanoparticles—into cells, offering a promising avenue for future therapeutic applications. However, the exact pathways underlying their cellular uptake remain a subject of ongoing debate. Our research focuses on studying multiple CPPs to uncover their unique transport mechanisms and shed light on their interactions with various lipid molecules.
Publications
Insights into translocation of arginine-rich cell-penetrating peptides across a model membrane
It is well-known that membrane deformation and water pores contribute to the spontaneous translocation of arginine-rich …
Spontaneous translocation of cell-penetrating peptides across a model membrane using molecular dynamics simulations
Observing the spontaneous translocation of cell-penetrating peptides across a lipid bilayer in molecular dynamics simulations is …
Spontaneous translocation of cell-penetrating peptides using the weighted ensemble method within molecular dynamics simulations
Our findings demonstrate the occurrence of self-induced translocation of a specific cell-penetrating peptide (CPP) across a model …
External electric field effect on the translocation of R-derivatives peptides across a symmetric lipid bilayer using umbrella sampling
Translating cargoes like nanoparticles (NP) and macromolecules like DNA and RNA across the model membrane through different …
Translocation of cell-penetrating peptides using the weighted ensemble method within molecular dynamics simulations approach
We report spontaneous translocation of a single cell-penetrating peptide (CPP) across a model membrane using the weighted ensemble (WE) …
Translocation of a single Arg9 peptide across a DOPC/DOPG(4:1) model membrane using the weighted ensemble method
It is difficult to observe a spontaneous translocation of cell-penetrating peptides(CPPs) within a short time scale (e.g., a few …
Translocation of cell-penetrating peptides across a model membrane using molecular dynamics simulations
In this study, we report a single Arg9(R9) peptide translocation across a DOPC/DOPG(4:1) model membrane within an order of a few tens …
Translocation of a single Arg9 peptide across a DOPC/DOPG(4:1) model membrane using the weighted ensemble method
A spontaneous translocation of cell-penetrating peptides(CPPs) in all-atom molecular dynamics(MD) simulations is not expected within a …
Free energy analyses of cell-penetrating peptides using the weighted ensemble method
Cell-penetrating peptides (CPPs) have been widely used for drug-delivery agents; however, it has not been fully understood how they …
Free energy analyses of cell penetrating peptides using the weighted ensemble method
Cell penetrating peptides (CPPs) have been widely used for drug-delivery agents, however, it has not been fully understood how they …
Free energy analyses of cell penetrating peptides using the weighted ensemble method
Cell penetrating peptides (CPPs) have been widely used for drug-delivery agents, however, it has not been fully understood how they …
Enhancement of direct membrane penetration of cell-penetrating peptides (CPPs) by polyprolines
The transport mechanism of cell-penetrating peptides (CPPs) has not been fully understood and there seems no general rule to design …
Molecular dynamics studies of interactions between Arg9(nona-arginine) and a DOPC/DOPG(4:1) membrane
It has been known that the uptake mechanisms of cell-penetrating peptides (CPPs) depend on the experimental conditions such as the …
